Cardiac regeneration with pluripotent stem cell-derived cardiomyocytes and direct cardiac reprogramming
نویسندگان
چکیده
منابع مشابه
Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons
Direct reprogramming of somatic cells has been demonstrated, however, it is unknown whether electrophysiologically-active somatic cells derived from separate germ layers can be interconverted. We demonstrate that partial direct reprogramming of mesoderm-derived cardiomyocytes into neurons is feasible, generating cells exhibiting structural and electrophysiological properties of both cardiomyocy...
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Today, the only available curative therapy for end stage congestive heart failure (CHF) is heart transplantation. This therapeutic option is strongly limited by declining numbers of available donor hearts and by restricted long-term performance of the transplanted graft. The disastrous prognosis for CHF with its restricted therapeutic options has led scientists to develop different concepts of ...
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The mammalian heart has little capacity to regenerate, and following injury the myocardium is replaced by non-contractile scar tissue. Consequently, increased wall stress and workload on the remaining myocardium leads to chamber dilation, dysfunction, and heart failure. Cell-based therapy with an autologous, epigenetically reprogrammed, and cardiac-committed progenitor cell source could potenti...
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ژورنال
عنوان ژورنال: Regenerative Therapy
سال: 2019
ISSN: 2352-3204
DOI: 10.1016/j.reth.2019.06.004